Comparative Study of Photochemically Generated Conjugated Ortho- and Para-Quinone Methide Reactivity

Isomeric ortho- and para-quinone methides, while possessing similar electronic structures, show very different properties. o-Quinone methides (oQM) are more reactive towards nucleophiles and undergo very fast and efficient inverse electron-demand-Diels-Alder (IEDDA) reaction with electron-rich alkenes. p-Quinone methide, while also acting as Michael acceptors, is not reactive in IEDDA.

Type of Event:

Total Syntheses of Pepluanols A and B

Euphorbia is a large and diverse genus of flowering plants in the spurge family, comprising more than 2,000 species.1,2 Many of them have long been used in herbal folk medicine. In 2016 and 2018, Qiu and co-workers isolated five diterpenoids, pepluacetal and pepluanols A–D, from Euphorbia peplus.3,4 All five compounds show effective inhibitory activity on the KV1.3 voltage-gated potassium channel.

Type of Event:

Fall 2021 Course Schedule

IMPORTANT: Instructor assignments for sections of General and Organic Chemistry are subject to change at any time.  This course schedule is for planning purposes only; Athena is the official source of record for available course offerings.

Please note that a single course may have multiple meeting times and locations, and be sure to factor that into your schedule planning.