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Chemistry Graduate Student Wins Prestigious AAAS Award

A graduate student in the department of Chemistry, Ms. Cynthia Tope, has been selected to receive the 2020 Helen F. Holt Scholarship for Early Career Women in Science by the American Association for the Advancement of Science (AAAS). The award, to a single recipient, recognizes an outstanding graduate student who will be making a research presentation at the annual national AAAS meeting. The award includes funds to offset the cost of travel to the conference, held this year is Seattle, WA, conference registration, and AAAS membership. Ms.

How Metal Ions in the Brain Tip the Toxic Balance of the Killer Prion Protein

A prion is a misfolded form of the cellular prion protein, PrPC. Although the role of PrP in neurodegeneration was established over 30 years ago, there is little understanding of the protein’s normal function, and how misfolding leads to profound disease. Recent work shows that PrPC coordinates the cofactors Cu2+ and Zn2+, and regulates the distribution of these essential metal ions in the brain. Moreover, these metals stabilize a previously unseen fold in PrPC, the observation of which provides new insight into the mechanism of prion disease.

Destroying Toxic Amyloid-beta Aggregation with Photoactive Transition Metal Complexes

Alzheimer’s disease (AD) is a progressive neurodegenerative disease, characterized by memory loss, motor skill loss, and eventually death that currently affects at least 5.8 million Americans.1 This number is projected to more than double in the next 30 years.1 Much effort has gone into determining the exact cause of onset of AD as well as developing strategies to mitigate its symptoms, however, there are currently are no substantial methods of prevention, slowing, or cure.1 For nearly 30 years, the prevailing hypothesis for AD c

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