Nitric oxide (NO^•) has long attracted interest in chemistry and biochemistry. In fact the establishment of NO^• as the endothelium-derived relaxing factor (EDRF) won the Nobel Prize in Chemistry and Physics in 1998^1-3 and established its vital role in cardiovascular signaling. It has since been used as a first line of defense in the treatment of heart failure.

Reasoning about structure, reactivity, and chemical processes is a critical competency for organic chemistry students. Yet many students cannot fully interpret or explain the underlying chemical reasoning behind the many representations we use to depict chemical phenomena. We need to know more about how to scaffold students reasoning as they learn to translate and make meaning of the symbols and language of organic chemistry.

The first part of the talk describes experimental studies of molecular-weight growth pathways leading to PAH formation under combustion conditions, focusing on resonantly stabilized radicals, strained aromatic intermediates, and radical–radical chain-propagating (“well-skipping”) chemistry. Three complementary studies highlight the importance of five-membered-ring motifs in curved aromatic growth.

Atmospheric pollutants, ranging from traditional organic aerosols to emerging contaminants such as nanoplastics and per- and polyfluoroalkyl substances (PFAS), play critical roles in air quality, climate forcing, and environmental health. Yet their sources, atmospheric transformations, transport pathways, and impacts remain poorly constrained.

Cycloaddition reactions have been recognized as a robust method to construct carbocyclic or heterocyclic systems in a highly convergent manner through a concerted or stepwise mechanism since the original discovery of the Diels-Alder reaction. N-Heterocyclic compounds are considered “privileged structures” in pharmaceutical and medicinal chemistry for their core structure being present in many biologically active molecules and building blocks.

This talk will follow one major track through my research over the past half century. It starts with how soot forms in fuel rich flames and the resultant fractal morphology. This fractal nature is universal to all aggregating systems of solid particles and, as I will explain, can ultimately lead to gelation. Experiments to create aerosol gels in closed chambers led to the chance discovery of a viable method to make multi-layer graphene of commercial value.

Lipids are vital for cellular functions, acting as structural components, signaling molecules, and energy sources. Their metabolism, particularly through cytochrome P450s and other oxidizing enzymes, plays a key role in inflammation and disease. This study uses biochemical, analytical, and biophysical methods to examine the metabolism of endocannabinoids (a class of signaling lipids) and minor cannabinoids by membrane-bound cytochrome P450s, stabilized in nanoscale lipid bilayers (Nanodiscs).