Tags: Organic Seminar

Boron chemistry is an indispensable tool in modern organic synthesis, leveraging boron's unique electronic and structural properties. Established applications, such as the hydroboration reaction and the Suzuki-Miyaura cross-coupling, highlight its broad utility. This seminar will delve into novel uses of boron that enable the rapid synthesis of complex molecules with broad applications, including the development of alkene carboboration reactions…

The critical role that carbohydrates and their conjugates play in biological interactions is of interest in medicinal research, making the chemical synthesis of these molecules essential.1 The complexity of carbohydrates, due to their configuration, connectivity, and composition, makes the chemical synthesis lengthy and complicated.1 All these factors make synthesizing the stereoselective oligosaccharide a significant challenge.  Here, we…

The formation of carbon-carbon bonds is a long-standing challenge in synthetic organic chemistry primarily addressed in recent decades via cross-couplings. Cross-coupling has grown to be a powerful tool in organic synthesis in both research and industrial settings, winning the Nobel Prize in 2010. Traditional cross-couplings are primarily held back by the sensitivity of their reagents, and their limitations in forming saturated carbon-…

Over the past century, one of the most enduring challenges in drug discovery has been the large proportion of the human proteome considered “undruggable.” The key reasons are twofold: most protein surfaces are relatively flat, and many proteins are unstructured and highly flexible. As a result, over 85% of human proteins remain inaccessible to traditional small-molecule inhibitors. Furthermore, conventional inhibitors are typically reversible,…

Asymmetric C–H functionalization offers a direct and efficient approach for constructing chiral C–C and C–X bonds, streamlining access to complex molecules. Traditionally, this transformation relies on transition metal catalysis using noble metals such as iridium and rhodium, however their scarcity and high cost limit widespread application. To address these challenges, the Cramer group explored cobalt(III) as a more abundant alternative,…