Tags: Organic Seminar


Literature Seminar: "Total Synthesis of
(±)-Dhilirolide U"

Dhilirolide U is a highly oxygenated fungal meroterpenoid derived from 3,5-dimethylorsellinic acid (DMOA). Its unique 6/6/6/5/5 pentacyclic framework, featuring a densely functionalized bicyclo[3.2.1]octane core fused to a γ-lactone, presents significant challenges for chemical synthesis. In 2026, Carreira and coworkers reported the first total synthesis of (±)-dhilirolide U, employing a series of strategically designed transformations to…


Electrochemical and Photocatalytic Strategies for Selective Alcohol, Amine, and Hydrocarbon Functionalization

Our research program focuses on developing selective and sustainable synthetic methods that streamline the preparation of functionalized molecules from abundant and readily available feedstocks. In particular, we are interested in photocatalytic and electrochemical strategies that generate radical and radical ion intermediates, leveraging the unique reactivity of these open-shell species to achieve challenging bond constructions under mild…


Research Seminar: “Peroxide-Free, N-O Bond Forming Synthesis of Trisubstituted Hydroxylamine Using 1,2-Oxazetidine as Electrophilic Oxygen Source”


Research Seminar: "Study of Hydroxylamine Bioisosteres of FRAX1036 and IDRx-42"


Literature Seminar: "Synthesis of Pyrroles from Isoxazoles via Single-Atom Skeletal Editing"


Trials into Triumphs: The Emergence of a Concise Total Synthesis of Hinckdentine A


Divergent Total Synthesis of Pleurotinoid Natural Products


Divergent Total Synthesis of the Harziane Diterpenoids


Research Seminar: "New Aza-Diels–Alder Strategies"

Aza-Diels–Alder reactions are powerful tools for building nitrogen heterocycles, which are found throughout natural products, pharmaceuticals, and bioorthogonal chemistry. However, conventional aza-dienophiles often show poor reactivity. Although 1,2,4,5-tetrazines are widely used as dienes in bioorthogonal ligation, bi-tetrazines have been reported only once, through a harsh, low-yielding route, and their Diels–Alder reactivity has remained…


A New Pericyclic Approach to Cyclopentanes

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