Effects of Production Conditions and Environmental Aging on Solid-Phase and Dissolvable Pyrogenic Organic Matter Characteristics Pyrogenic organic matter (PyOM, aka ‘black carbon’) generated via the incomplete combustion of biomass or fossil fuels is an important component in soil, atmospheric, sedimentary, and aquatic environments. In particular, the condensed aromatic compounds (ConAC) in PyOM are slow-cycling rendering them important to global carbon cycles and the sequestration of carbon in soils. Type of Event: Analytical Seminar Read more about Effects of Production Conditions and Environmental Aging on Solid-Phase and Dissolvable Pyrogenic Organic Matter Characteristics
The Pursuit of How Structure Impacts Function: from Lipids to Oligonucleotides The functional role of a biological molecule hinges on its unique structure. The context by which structure impacts function is a vital piece of information that can provide insight into underlying biological processes. One set of biological molecules that have received renewed interest for their biological significance and potential role as markers of cellular dysfunction are lipids. Type of Event: Analytical Seminar Read more about The Pursuit of How Structure Impacts Function: from Lipids to Oligonucleotides
The UGA Center for Applied Isotope Studies: What We Do and Why The Center for Applied Isotope Studies (CAIS) is a multidisciplinary scientific research unit and core service facility within the UGA Office of Research that specializes in the quantification of isotope ratios using mass spectrometry. Type of Event: Analytical Seminar Read more about The UGA Center for Applied Isotope Studies: What We Do and Why
Quantitatively Evaluate the Orientation of the Axis of α-Helical α-Synuclein(61-95) in Monolayer with Residue Level Resolution by pMAIRS Significant scientific attention has been spent on the elucidation of protein’s structure to explain its function. Lots of proteins stay around cell membrane or vesicles to facilitate cellular metabolism. These proteins usually form monolayer structure around cell membrane/vesicles and therefore cause challenges for the measurements of X-ray crystallography and NMR, which cannot provide high resolution results for proteins in monolayer. Type of Event: Analytical Seminar Read more about Quantitatively Evaluate the Orientation of the Axis of α-Helical α-Synuclein(61-95) in Monolayer with Residue Level Resolution by pMAIRS
Characterization of Glycation and Other PTMs in Biotherapeutics Using HILIC-MS Glycation is an important post-translational modification that is linked to diabetes, cataract, Alzheimer’s, Rheumatoid arthritis and Parkinson’s disease.1 This reaction occurs between a reducing sugar and a primary amine at the N-terminus of protein or the sidechain of Lysine residues. Ultimately this interaction leads to advanced glycation end products (AGEs) that are associated with several disease complications.2 Glycation could also occur during the manufacturing and storage of therapeutic proteins, Type of Event: Analytical Seminar Read more about Characterization of Glycation and Other PTMs in Biotherapeutics Using HILIC-MS
Investigating Analytical Techniques for Microplastic Characterization and Quantification Exposure to microplastics and nanoplastics throughout daily life is inevitable, yet still poses a variety of unknowns and concerns in biological and environmental systems. Microplastics are defined by the National Oceanic and Atmospheric Association (NOAA) as all plastic particles <5mm in size; either produced to be that size (primary) or via degradation of larger particles (secondary). Ubiquitous in nature, microplastics have successfully infiltrated marine systems, foodstuffs, soil/sediments, and biological systems. Type of Event: Analytical Seminar Read more about Investigating Analytical Techniques for Microplastic Characterization and Quantification
Measuring Photolytic Mass Loss of Humic Substances with a Quartz Microbalance(QCM) Secondary organic aerosol (SOA) is formed in the atmosphere through the oxidation of volatile organic compounds (VOCs) and represents a significant portion of global submicron-sized atmospheric organic aerosol. SOA plays a crucial role in multiple processes that impact climate and human health. Type of Event: Analytical Seminar Read more about Measuring Photolytic Mass Loss of Humic Substances with a Quartz Microbalance(QCM)
Monitoring of Spent Nuclear Fuel Treatment Steps by Analytical Methods to Improve Efficiency Nuclear power has broad application prospects as a kind of clean energy. One of the biggest controversies in the development of nuclear energy has been the potential environmental impact of spent fuel (SNF), which is the raw material of incomplete reactions and toxic byproducts. At present, people still use landfills to deal with SNF residues, whether for low-level radioactive wastes or high-radioactive wastes after separation and transmutation. Effective monitoring methods will greatly reduce the environmental hazards of these landfil Type of Event: Analytical Seminar Read more about Monitoring of Spent Nuclear Fuel Treatment Steps by Analytical Methods to Improve Efficiency
Total Synthesis of the Herqulines The herquline family of natural products were originally isolated from penicillium herquei in 1979 by the Ōmura group (see figure below). These strained macrocyclic alkaloids all contain multiple stereocenters, and an unsymmetrically substituted piperazine. Herqulines B and C feature two β,γ-unsaturated cyclohexenones, while herquline A bears an additional pyrrolidine. Type of Event: Organic Seminar Read more about Total Synthesis of the Herqulines
Metal–Hydrogen Atom Transfer (MHAT)-Initiated Intramolecular Giese Reactions in Total Synthesis The use of metal–hydrogen atom transfer (MHAT) for olefin hydrofunctionalization has received great attention over the last 20 years, primarily due to its enhanced chemoselectivity and regioselectivity.[1] The Giese reaction, or the addition of a carbon-centered radical into an electron-deficient alkene, is well-known and has been commonly employed for C–C bond formation over the last 40 years.[2] More recently, the Baran group coupled these two methodologies to establish a powerful tool for the reductive cross-coupling of Type of Event: Organic Seminar Read more about Metal–Hydrogen Atom Transfer (MHAT)-Initiated Intramolecular Giese Reactions in Total Synthesis