Oxidative Coupling Reactions of Phenols and Azines Via Cationic and Radical Intermediates

The photochemical oxidative coupling of phenols with a range of coupling partners will be described. Even though the reaction likely involves radical intermediates, selectivity can be controlled by selecting coupling partners with different oxidation and nucleophilicity profiles. In addition, the use of donor acceptor complexes permit coupling with partners that have lower oxidation potentials than the phenols. The use of solid photocatalysts and the removal of product to prevent overoxidation will be also be outlined. 

Marisa Kozlowski completed undergraduate studies at Cornell University and graduate studies at the University of California at Berkeley. After a National Science Foundation fellowship at Harvard University, she joined the faculty at the University of Pennsylvania and currently is the inaugural holder of the Lu Professor of Chemistry endowed by Roy and Diana Vagelos. She is also Associate Dean of the Natural Sciences. The major focus of Professor Kozlowski's research is the development of new catalytic methods for efficient organic synthesis using computation and high throughout screening. Professor Kozlowski's contributions have been recognized by a Sloan Research Fellowship, the Philadelphia Organic Chemists’ Club Award, the Philadelphia ACS Section Award, a ACS Cope Scholar Award, and and the Leete Award.  She has been elected as a Fellow of the American Association for the Advancement of Science and the American Chemical Society. For innovations in teaching and mentoring, she has received the Kahn Award for Distinguished Teaching, the Charles Ludwig Distinguished Teaching Award, the Dennis DeTurck Award for Innovation in Teaching, and the Provost Award for PhD Teaching and Mentoring. In addition to over 200 independent publications, Professor Kozlowski coauthored with Professor Patrick Walsh the book “Fundamentals of Asymmetric Catalysis," available from University Science Books. She is currently Editor-In-Chief of Organic Letters.