Tags: Organic Seminar


Recent Advances in Electrocatalytic C-H Activation

Electrolysis in synthetic organic chemistry has a rich history dating back to the 19th century. Many advances have been done with the use of electrolysis in the past, e.g. Kolbe’s decarboxylative dimerization, 1 Tafel’s electrolytic rearrangement, 2 Simmons’s C-H fluorination.3 Since then the popularity of the electrolysis in synthetic organic chemistry has drastically decreased. In the past decade transition metal-catalyzed C-H…


AaronJr: Automates Any Reaction or Optimization, Normally Just Right

Despite the ever-increasing availability and applicability of computational methods to questions of chemical significance, many chemists from purely experimental backgrounds find it difficult to begin integrating these methods into their research. To reduce this barrier of entry and catalyze non-computational chemists’ ability to take advantage of the insights computational studies can provide, we have developed a suite of tools, collectively…


Synthesis of Chemical Tools for the Study of Protein O-Mannosylation

Glycosylation of certain proteins by oxygen-linked mannose (O-mannose) is known as O-mannosylation, and this process is essential for growth and development in animals.1-4 Defective O-mannosylation of α-dystroglycan, the most well studied O-mannosylated mammalian protein, leads to congenital muscular dystrophies and neurological defects.4-6 Mannose is linked to proteins through the serine or threonine side chain oxygen. Glycosyl transferase…


Road to Phorbol

Phorbol, a Tigliane natural product first isolated in 1934 by Dr.Flaschenträger and Dr. Wolffersdorff, drove 17 research groups to develop the synthesis of it for over 30 years and report over 40 synthesis papers because of their potent biological activities to promote the tumor by activation of the protein kinase C and the anticancer activity.  The structure of the phorbol, first determined by Dr. Heck in 1967, was a congested tetracyclic…


The Design of Molecular Scaffolds for C-H Functionalization

Bond formation via metal-catalyzed selective C–H functionalization is well appreciated and often relies on the directing capability of the substrate. That is, the appropriate positioning of a Lewis basic functional group can present the metal catalyst center at a specific site, enabling activation of otherwise unreactive C–H bonds. The Lewis basicity of alcohols can be exploited to impart directing capabilities allowing for the capacity to…


Probing the Mechanism(s) of Sialidation Reactions Using Cation Clocks

The first part of my talk centers on the application of cation clock reactions for the determination of relative reaction kinetics in sialidation reactions. The formation of glycosidic bonds is perhaps the most important bond forming reaction in glycoscience, playing a critical role in the assembly of all glycoconjugates. In general, the control of the glycosylation reaction is a key ingredient to engineering better stereoselective…


Influence of the Side Chain Conformation on Glycosylation Selectivity in Furanosides

Glycosylation reactions stereoselectivity depends on various factors and among them, side-chain configuration and conformation have been showing significant roles in influencing the reactivity and selectivity in bicyclic glycosyl donors. Moving to monocyclic donors, this effect has been revealed in glycosylation reactions of sialic acid donor series and simple pyranoside series. We studied the extension of this concept towards furanosides by…


Glycosylation Methods in the Total Synthesis of Complex Glycosylated Natural Products

Carbohydrates are the most abundant class of molecules in the biosphere. Glycosylated secondary metabolites play a major role in carbohydrate chemistry expanding the scope of potential drug motifs. Glycosylated natural products are made out of sugars covalently O-, C-, N- or S- linked to the aglycone counterpart. In the course of synthesizing potential glycosidic therapeutics, effective and straightforward regio and stereoselective glycosylation…


Alternatives to Per- and Polyfluoroalkyl Substances for Food Packaging

Per- and Polyfluoroalkyl substances (PFAS’s) are widely used to coat paper and cardboard for food packaging because of their desirable grease, water, and heat resistant properties. However, the US FDA has raised concerns regarding the safety of these materials, citing the potential of degradation products to persist in rodents after repeated exposure, and known health risks of similar molecules. 1 In recent years, the US FDA and the EPA have…


Aminoglycoside Antibiotic Derivatization and Glycosidase Transition State Stabilization through Substrate Side Chain Restriction

The first half of the talk focuses on aminoglycoside antibiotics, highly active protein synthesis inhibitors that impact a wide range of both Gram positive and Gram negative bacteria. Though these drugs have many benefits and currently find use in the clinic, they can bring about reversible nephrotoxicity and irreversible ototoxicity. Thanks to its unusual structure, the aminoglycoside apramycin, while less active, exhibits significantly lower…
Subscribe to Organic Seminar

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: chemreg@uga.edu 

Registration and credit transfers: chemreg@uga.edu

AP Credit, Section Changes, Overrides, Prerequisites: chemreg@uga.edu

Graduate inquiries: chemgrad@uga.edu

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email: chem-web@franklin.uga.edu

Head of Chemistry: Prof. Jason Locklin