Tags: Organic Seminar


In Situ Cross-linkable Hydrogel via Strain-Promoted Azide-Alkyne Cycloaddition

Alginate is a family of natural origin polysaccharides which could be utilized in hydrogel preparation at mild pH and physiological conditions. The hydrogel based on alginate performed particular relevance on wound dressing materials for the treatment of acute or chronic wounds due to the high water content, biocompatibility, flexibility, porosity, smoothness and ability to incorporate and release therapeutic agents. In this project, we designed…


Synthesis And Assays of SAM-Based Inhibitors of Methyltransferases

Gene expression and transcription are critical for a variety of cellular processes and are controlled not only by DNA sequence and transcription factors but also by epigenetic regulation1. Epigenetic regulation requires site-specific modification of the genome and is involved in multiple physiological processes and disease etiology1. Methyltransferases, which catalyze the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to…


Cyclic Carbonates and Non-Isocyanate Polyurethanes: CO2 as a Building Block for High-Performance Polymers

The production of commodity plastic is predicted to increase substantially in upcoming decades.1 Many common plastics are derived from petroleum, which is a finite resource. Because of this, much work has been done to design materials based on sustainable feedstocks.2 Carbon dioxide, which is abundantly available, is an appealing source of carbon and is already used in numerous chemical processes.3 In this presentation, the reaction of carbon…


Mechanistic Study and Application of Decarbonylation of Cyclopropenone

Cyclopropenone is an organic compound consisting of cyclopropene framework with a ketone functional group. It has been found in various natural compounds. Cyclopropenone can also undergo different kinds of reactions but most of the reactions can be categorized to nucleophilic attack and decarbonylation. Although photodecarbonylation is the one of the most common reaction of cyclopropenones, there is very little agreement in the literature on the…


Comparative Study of Photochemically Generated Conjugated Ortho- and Para-Quinone Methide Reactivity

Isomeric ortho- and para-quinone methides, while possessing similar electronic structures, show very different properties. o-Quinone methides (oQM) are more reactive towards nucleophiles and undergo very fast and efficient inverse electron-demand-Diels-Alder (IEDDA) reaction with electron-rich alkenes. p-Quinone methide, while also acting as Michael acceptors, is not reactive in IEDDA. The photochemical generation of o-naphthoquinone methide (o…


Total Syntheses of Pepluanols A and B

Euphorbia is a large and diverse genus of flowering plants in the spurge family, comprising more than 2,000 species.1,2 Many of them have long been used in herbal folk medicine. In 2016 and 2018, Qiu and co-workers isolated five diterpenoids, pepluacetal and pepluanols A–D, from Euphorbia peplus.3,4 All five compounds show effective inhibitory activity on the KV1.3 voltage-gated potassium channel. Thus, they are potential candidates for the…


Design, Development and Planned Proof of Concept for a Gate Functionalized Drug Delivery Metal Organic Framework (MOF)

It might be an understatement in saying the interest in Metal Organic Frameworks (MOFs) and their vast array of topologies, constitutions and applications have incurred great interest over the past two decades. Many areas of chemical research have been impacted in the potential that MOFs bring to the table. These include gas storage and separations, chemical catalysis, endeavors in the removal of harmful and toxic environmental chemicals,…


The Total Synthesis of Daphniphyllum Alkaloids

Daphniphyllum alkaloids have a rich history dating back to the isolation of Daphniphyllum macropodum Miquel in 1909 by Yagi.1 Pioneering work in the 1960s by Hirata and colleagues resulted in the isolation of daphniphylline and yuzurimine alkaloids, and subsequently, a total of over 330 Daphniphyllum alkaloids have been reported from the Daphniphyllum genus.2-5 In view of their intriguing biological activities including anti-cancer and  …


Advances in Chromium(III) Photocatalysis: Catalyst Design and Reaction Development

Over the past few decades, photoredox catalysis has emerged as a powerful tool for new bond formation. Acting as an oxidant or a reductant, an excited-state metal complex can generate reactive radical intermediates via a single-electron transfer process. The most commonly used transition-metal photocatalysts are ruthenium or iridium complexes. Our group has utilized chromium(III) complexes in a variety of different photoredox transformations.…


The Valorization of Lignin and its Roles in the Landscape of Bio-Based Materials

Lignin is the world’s second most abundant biopolymer and the world’s largest source of biobased aromatics (1). Occurring as an adhesive which binds together the cellulose fibers in the cell walls of woody plants, lignin has been largely cast aside as a waste byproduct of pulping procedures. Since the main industrial pulping procedures focus on the production of paper, the fate of lignin usually involves combustion to produce heat (2). This…
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