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Slideshow

In Situ Cross-linkable Hydrogel via Strain-Promoted Azide-Alkyne Cycloaddition

Chen Zhao, speaker
Chen Zhao
Graduate Student, Department of Chemistry
University of Georgia
Chemistry Building, Room 400
Organic Seminar

Alginate is a family of natural origin polysaccharides which could be utilized in hydrogel preparation at mild pH and physiological conditions. The hydrogel based on alginate performed particular relevance on wound dressing materials for the treatment of acute or chronic wounds due to the high water content, biocompatibility, flexibility, porosity, smoothness and ability to incorporate and release therapeutic agents. In this project, we designed a linker to achieve alginate gelation via SPAAC (strain-promoted azide-alkyne cycloaddition). The sodium salt of alginates was chemically modified with azide groups to prepare precursor polymers of Alg-azide (Alg-N3). A bis-azadibenzocyclooctyne (bisADIBO) was designed as a crosslinker for alginate gelation. Since Azadibenzocyclooctyne (ADIBO) shows high reactivity towards azides even at aqueous condition and it has long shelf life. The bis-ADIBO should enable the covalent, catalyst free crosslinking for Alg-N3 and maintain the biocompatibility at the same time.

Chen Zhao organic seminar image

References

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