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Tags: Analytical Seminar

Aptamers are ribonucleic acids (RNA) or single-stranded DNA (ssDNA) molecules that demonstrate high affinity and specificity for a wide range of targets.  These molecules possess several advantages such as good tissue penetration and are easily modified for increased stability and combination therapy.  Consequently, aptamers are used as drugs and diagnostic tools. Bioimaging, analytical reagents, and toxin/hazardous chemical detection…
Glycosylation is an important and common post translational modification in proteins. Glycoproteins are proteins that carry one of more glycans covalently attached to a polypeptide backbone, usually via N- or O-linkages. One of the most abundant glycoproteins in human serum is Immunoglobulin G (IgG), a type of antibody. IgG is composed of four subunits, two identical light chains and two identical heavy chains, forming a structure with twofold…
Surfactants are organic molecules that have surface active properties that reduce the surface tension of solutions. Surfactants can be found in marine water systems and originate from both natural and anthropogenic sources. These compounds are characterized by having a hydrophilic head and a hydrophobic tail. This chemical structure causes surfactants to accumulate and orient themselves on the surface of the ocean in a microlayer of organic…
The Chemistry Graduate Student Organization Networking Committee would like to have an open roundtable discussion about the importance of personal development and networking as a student progressing through graduate school and preparing for an evolving job market. A sense of community is an important part of having a successful graduate career and generating discussion is an important way of making such progress. To lead the discussion,…
The diverse post translational modifications (PTMs) add up the already enormous in number, meanwhile low abundance for certain species of proteomes with even more complexity. As efforts to enrich peptides and proteins of interest out of complex mass spectral background, various fractionation, separation, enrichment, and feature detection strategies are extensively implemented. Hydrophilic interaction chromatography (HILIC), and its varieties are…
This week, there will be three-minute thesis presentations from nine senior graduate students: Zhengwei Chao, Cynthia Tope, Rob Williams, Yongwook Kim, Tret Burdette, Lily Birx, Fangchao Jiang, Tanvir Ahmed, and Yiqing Zhang
One of the major challenges facing intravenous nanoparticle administration is the formation of protein coronae on the surface of injected nanoparticles, which prevents them from reaching the target tissue. Biocompatible ionic liquids (ILs) have been shown to have tunable interactions with biomolecules including proteins and are prone to rearrangement on charged surfaces. We show that this can be exploited to use designer protein avoidant-ionic…
Despite formaldehyde being a known carcinogen, it is frequently used in cosmetic products as a preservative due to its antimicrobial properties. The FDA lists formaldehyde (FA) and formaldehyde releasers (FR) as common allergens in cosmetic products. According to the European Union, up to 2000 ppm of formaldehyde is permitted in cosmetics but quantifying free formaldehyde from formaldehyde releasers in cosmetics can be challenging.2 Formaldehyde…
Metabolomics is the study of the collective small molecules within a biological system (cell, tissue or whole organism). The study of these small molecules (metabolites) gives a close measure of the phenotype, giving insight into an organism’s physiological and biochemical state at the time of sample collection. Thus, metabolomics has emerged as a highly attractive field employed to study normal physiology and changes in physiology due to…
Traditional tandem mass spectrometry, an analytical technique that isolates a precursor ion then fragments it to obtain structural information, is a method extensively used in analytical chemistry. Coupling different separation methods, like LC and GC, can help study complex mixtures that may be difficult with MS/MS alone. However, the isolation step requires a sufficient signal threshold of the precursors, preventing low signal ions that may…

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