Sayani Roy Chowdhury Graduate Student, Department of Chemistry University of Georgia Learn more about the speaker Thursday, March 30, 2023 - 11:10am iSTEM Building 2, Room 1218 Organic Seminar Metal-Organic Frameworks (MOFs) since their discovery has been used in a variety of applications, including, but not limited to gas adsorption and storage, food packaging, biofilms and drug delivery due to the vast array of options for its component parts (the metal nodes and the organic linkers) and its high surface area and high porosity. Recently, there has been a surge of MOFs in the drug delivery realm, especially in the active release of cargo from the MOF since it offers a better spatial and temporal control. Herein, we present a novel “door-opening” MOF to release the encapsulated cargo via irradiation. This design will serve as a proof of concept in using a photolabile “gate” moiety that will encapsulate the test drug in the MOF till it is irradiated at 365 nm. The synthesis and characterization of the MOF will be discussed alongside the characterization mechanisms planned further into the project. Selected References a) Wenhao Shen, Jun Zheng, Zhansong Zhou, Dinglin Zhang. Approaches for the synthesis of o-nitrobenzyl and coumarin linkers for use in photocleavable biomaterials and bioconjugates and their biomedical applications. Acta Biomaterialia. 2020, 115 (1) 75. b) Moon Suk Kim, Scott L. Diamond. Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications. Bioorganic & Medicinal Chemistry Letters. 2006, 16 ,4007. Yingwei Li and Ralph T. Yang. Gas Adsorption and Storage in Metal−Organic Framework MOF-177. Langmuir 2007, 23,12937. Horcajada P, Serre C, Vallet-Regí M, Sebban M, Taulelle F, Férey G. Metal-organic frameworks as efficient materials for drug delivery. Angew. Chem. Int. Ed. Engl. 2006, 45, 5974.
