Skip to main content
Skip to main menu


Biochemically Responsive MRI Contrast Agents

Headshot of Adrian Torres, speaker, man with dark hair and patterned shirt
Adrian Torres
Graduate Student, Department of Chemistry
University of Georgia
iSTEM-2 Building, Room 1218
Inorganic Seminar

Magnetic Resonance Imaging is a diagnostic method used to image organs and soft tissue in the body. The instrument relies on the use of magnets and radiofrequency radiation to examine the proton nuclei of water within tissue and organs. Through use of contrast agents, the images acquired can have improved detail which is critical for diagnoses of tumors, inflammation, and other abnormalities. These agents utilize paramagnetic metals to induce magnetic effects on the protons, enabling a change in proton relaxivity. Early contrast agent development involved use of gadolinium (III) transition metal complexes. Gadolinium-based contrast agents work well to improve contrast but are retained in the body indefinitely. The long-term use of gadolinium is not fully understood. This prompted developments of a new generation of contrast agents. These agents use endogenous, first-row transition metals such as Mn(II) and Fe(III). The contrast agents highlighted in this seminar exhibit unique strategies for contrast imaging such as site-specificity, MRI response modulation based on pH- and concentration- effects on paramagnetism, and redox-active MRI signaling in response to interactions with reactive oxygen species.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: 

Registration and credit

AP Credit, Section Changes, Overrides,

Graduate inquiries:

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Fax: 706-542-9454

Head of the Department: Prof. I. Jonathan Amster