Tags: Organic Seminar


TBA - Timothy Henkel


Applying X-Ray crystallography for elucidating enantioselective alcohol dehydrogenase/carbonyl reductase enzyme – substrate interactions

The use of microorganisms in fermentation for ethanol production or in bio-catalysis for drug synthesis has been attracting attention of scientist over the past few decades because it efficient, cost-effective, and environment-friendly. The aim of my research project is applying X-Ray crystallography to investigate the enzyme structures of enantioselective Alcohol dehydrogenase (ADH) and Carbonyl reductase (CAR) from these organisms to elucidate…


TBA - Jeff Costello


Proteomimetic Foldamers for Biomolecular Recognition


(Towards) The Rapid Generation of Structural Complexity


Controlling Chemical Reactivity: From Small Molecules to Polymers


Mechanistic Insights Facilitate the Development of Transition Metal Catalyzed Processes


New Strategies in Radical-Based Aliphatic C-H Fluorination

  In 2018, almost 50% of all small-molecule drugs approved by the FDA contained fluorine. The appeal of fluorine substitution in drug candidates can be attributed to the improved properties fluorine exerts on a molecule such as blocking undesired metabolism and increasing potency, absorption, or binding affinities. Incorporation of the radio isotope, [18F], to bioactive molecules also has applications in medical imaging as well as…


Cooperation of Experiment and Theory in Enzyme Design

Scientists have exploited enzymes as catalysts for various chemical transformations for over 30 years. The benefits of using enzymes over other synthetic catalysts are numerous and include their specificity, selectivity, and stability. These strengths can also be weaknesses; enzymes are often only active for a few substrates, while synthetic catalysts can often be readily-tuned to increase substrate scope. The directed evolution of enzymes has…


Towards automation in oligosaccharide synthesis

Carbohydrates are the most abundant molecules among the four essential classes of biomolecules that also include nucleic acids, lipids, and proteins. Unlike proteins and nucleic acids, which follow template-driven synthetic pathways, there is no general route to the synthesis of carbohydrates. This literature seminar will focus on the commonly used methods to synthesize oligosaccharides and the gradual movement of the field towards automation.
Subscribe to Organic Seminar