Tags: Organic Seminar


Organo Boronates, Phosphates, and Sulfates Synthesized by Fluoride Exchange Reaction and Their Applications in Vitrimer System

Sulfur-fluoride exchange (SuFEx) reaction was first demonstrated by Sharpless and his co-workers1 in 2014. SuFEx is now considered as the second generation of click chemistry. It was established on the silicon centers, which can activate the exchange of S-F bonds for S-O bonds. A strong base, like triazabicyclodecene (TBD), was usually considered as the catalyst of SuFEx. Since then, we started to explore the possibility of the reaction between…


Light-Induced Hydrogen Sulfide Release from o-Naphthoquinone Methide Precursors (NQMPs)

Hydrogen sulfide (H2S) is one of the important gasotransmitters, a family of small gaseous signaling molecules. According to recent publications, hydrogen sulfide possesses anti-inflammatory,1 anti-tumor,2 cardiovascular protective,3 and antioxidant4 activities. However, the biological response to H2S strongly depends on H2S concentration and the specific site in the system.5 The use of H2S gas or inorganic sulfides is problematic due…


Introduction to the Organic Seminar


Improvement of Poly-3-hydroxybutyrate-co-3-hydroxyhexanoate Nucleation for Use in Waterborne and Biologically Degradable Polymer Coating

Single-use plastics plague our oceans as landfills overflow and waste is mismanaged. Jambeck et al estimated that only 30% of all plastic ever produced are currently in use, and in 2015 only 9% was recycled.[1] The packaging and single-use plastics industry are two main contributors to this ever increasing amount of plastic production and pollution. To reduce waste accumulated in landfills the single-use abuse of environmentally persisting…


Cis/trans Photoisomerization: From Photoswitches to Light-Activated Molecular Rotary Motors

Over the past few decades synthetic chemists were striving to make a leap from simple molecular switches to molecular systems with controlled dynamic behavior. These research efforts were inspired by directional motion in living systems that are key to almost every essential process in the cell. The structure of molecular rotary motors resembles the layout of macroscopic electric motors which are widely used to convert energy into motion.…


TBA - Timothy Henkel


Applying X-Ray crystallography for elucidating enantioselective alcohol dehydrogenase/carbonyl reductase enzyme – substrate interactions

The use of microorganisms in fermentation for ethanol production or in bio-catalysis for drug synthesis has been attracting attention of scientist over the past few decades because it efficient, cost-effective, and environment-friendly. The aim of my research project is applying X-Ray crystallography to investigate the enzyme structures of enantioselective Alcohol dehydrogenase (ADH) and Carbonyl reductase (CAR) from these organisms to elucidate…


TBA - Jeff Costello


Proteomimetic Foldamers for Biomolecular Recognition


(Towards) The Rapid Generation of Structural Complexity

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