Tags: Analytical Seminar


Multi-Dimensional Separations for Bacteria Identifications and Investigations of Antimicrobial Resistance

Bacterial infections are a major global health concern, with an estimated 1 in 8 deaths attributed to bacterial infections in 2019 alone. When a patient with a suspected infection arrives in a clinical setting, the first step to developing a treatment strategy is to identify the causative pathogen, followed by determination of antimicrobial therapeutics that are appropriate and effective. The challenge for both these essential steps is the…


Imaging Biological Tissues at High Chemical and Spatial Resolutions Using Mass Spectrometry

Imaging mass spectrometry is a powerful analytical technique for analyzing the spatial lipidome. This technology enables the visualization of molecular pathology directly in tissues by combining the specificity of mass spectrometry with the spatial fidelity of microscopic imaging. This label-free methodology has proven exceptionally useful in research areas such as cancer diagnosis, diabetes, and infectious disease. However, state-of-the-art…


Two Tales of Measuring More than Mass with Mass Spectrometers: Differentiating Hydroxyproline Isomers and Understanding Ionic Liquid Degradation

We are broadly interested in using mass spectrometry-based platforms to learn more than just the mass about chemical species. During this talk two examples of this will be presented. In the first, infrared ion spectroscopy will be presented as one path toward direct structural probing of gas-phase ions, with the goal of isomer differentiation. Hydroxyproline isomers will be presented as a case study toward this effect. In the second, our work to…


In vitro Insights of Exogenous Fatty acids and FASII Inhibitors on Lipid Profiles and Antibiotic Susceptibilities in Staphylococcus aureus

The prevalence of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections is on the rise, primarily due to the rapid development of resistance mechanisms by S. aureus against commonly used antibiotics.1 Daptomycin, the last-resort antibiotic for MRSA, has encountered challenges as studies reveal acquired resistance by S. aureus.2 FASII is a distinct metabolic pathway associated in synthesis of fatty acids through a series…


Connecting Branched Isomer Distributions and Membrane Characteristics in Daptomycin-Resistant Staphylococcus aureus Using RPLC-IM-MS

Staphylococcus aureus is a common cause of hospital and community-acquired infections. Although uncommon, resistance to daptomycin is mediated by mutations in genes associated with the regulation, synthesis, or relocation of fatty acids and membrane lipids. These mutations influence physical properties such as cell surface charge, cell membrane fluidity, and daptomycin resistance, however, recent results were unable to provide an in-depth…


The MAW Method: A Rapid Single-Phase Extraction for Bacterial Lipidomics

The increasing incidence of antibiotic resistance underscores the pressing need for studies aimed at understanding its underlying mechanisms. Bacterial membrane lipids provide an avenue for studies, as they are crucial for maintaining the integrity and functionality of bacterial cell membranes. However, in-depth studies on the involvement of bacterial membrane lipids require working with numerous bacterial samples, which necessitates the need…


Intrinsically Disordered Proteins (IDPs): NMR Studies of IDPs

Intrinsically disordered proteins (IDPs) - polypeptides that lack a defined three-dimensional structure – are commonplace in eukaryotic proteomes and often have critical impact on correct functioning of biological processes. IDPs can mediate low affinity interactions between proteins and serve as a scaffold or intermediate binding agent. Malfunctions in IDPs can lead to protein aggregation and various diseases, such as Alzheimer's, Parkinson’s,…


Direct Mass Spectrometry Technologies for Intraoperative Tissue Analysis and Surgical Margin Evaluation

Surgical resection remains a primary treatment for solid tumors. However, achieving tumor-free margins during surgery is challenging. Residual cancer cells at surgical margins are associated with increased recurrence and reduced survival rates. Intraoperative evaluation of surgical margins could enable more complete resection and reduce positive margins. Traditional frozen section histopathology has limitations including time-consumption,…


Chemical and Physical Properties of Surfactants in Seawater and Aerosol Particles and Their Influence on Particle Hygroscopic Growth

The size and composition of atmospheric aerosol particles modulate their interactions with solar radiation, and thus their influence on climate and visibility. The radiative effects of aerosol particles remain a large uncertainty in accurately modeling and predicting current and future climates. Recent work has demonstrated the presence of organic surfactant molecules in atmospheric aerosol particles, and their sources and transformations in the…


Effects of Production Conditions and Environmental Aging on Solid-Phase and Dissolvable Pyrogenic Organic Matter Characteristics

Pyrogenic organic matter (PyOM, aka ‘black carbon’) generated via the incomplete combustion of biomass or fossil fuels is an important component in soil, atmospheric, sedimentary, and aquatic environments. In particular, the condensed aromatic compounds (ConAC) in PyOM are slow-cycling rendering them important to global carbon cycles and the sequestration of carbon in soils. Recently, the dissolvable component of PyOM (PyDOM) has received…
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