Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer


The Great ESKAPEE: Multi-Omic Methods for Bacterial Profiling Using HILIC-IM-MS

Portrait of Jana Carpenter, speaker
Jana Carpenter
Graduate Student, Department of Chemistry
University of Georgia
iSTEM Building 2, Room 1218
Analytical Seminar

The prominence of antibiotic resistant bacterial strains has raised concern for the efficacy of currently available antibiotics. Point-of-care utilization of existing drug therapies require strain specific identification of pathogens, which often demands tedious sample preparation strategies and tailored analytical methods. The emergence of multi-omics approaches has empowered scientists to answer complex systems biology questions regarding antibiotic resistance. The Centers for Disease Control disclosed in a 2019 report, identifying some of the most prominent multi-drug resistant bacteria, E.S.K.A.P.E.E. pathogens, that contribute to infection that may lead to high rates of mortality and increased economic strain from health-care associated costs. The genomic and proteomic information of these antibiotic resistant pathogens, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., and Escherichia coli have been thoroughly explored. However, there remains a significant lack of knowledge of the downstream metabolomic and lipidomic profiles of these small organisms. Here, we have optimized a high throughput multiomics approach that can isolate the constituent parts of the whole biological system that are not otherwise explained by the template-driven aspects of genomics and proteomics. We showcase the potential for a streamlined method for managing multi-omics experiments of diverse antibiotic resistant microbe populations using an optimized workflow.1 


(1) Carpenter, J. M.; Hynds, H. M.; Bimpeh, K.; Hines, K. M. ACS Measurement Science Au 2023.

Research Areas:

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: 

Registration and credit

AP Credit, Section Changes, Overrides,

Graduate inquiries:

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email:

Head of Chemistry: Prof. Jason Locklin