Skip to main content
Skip to main menu

Slideshow

Structural Basis for Catalytic Diversity in the Carotenoid Oxygenase Superfamily

Prof. Philip D. Kiser
Prof. Philip D. Kiser
Assistant Professor, Physiology & Biophysics
University of California, Irvine
Chemistry Building, Room 400
Department Colloquium

Carotenoid cleavage dioxygenases (CCDs) are mononuclear non-heme iron enzymes that classically split carotenoids at specific alkene bonds producing apocarotenoid products. Certain members of this enzyme superfamily have evolved to process alternative substrates with varying regio- and stereo-selectivity, and some catalyze alternative reactions including alkene geometric isomerization and ester hydrolysis. Products of these reactions are vital for a broad array of biological processes ranging from embryonic development and visual function in animals to drought resistance and pathogen susceptibility in plants. The importance of CCDs in biology coupled with the interesting variability in their catalytic activity has motivated efforts to understand the molecular inner workings of these enzymes. In this talk, I will discuss recent experimental findings from our laboratory that have shed light on the structural basis for some of the diverse catalytic functions found among CCDs.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: chemreg@uga.edu 

Registration and credit transferschemreg@uga.edu

AP Credit, Section Changes, Overrides, Prerequisiteschemreg@uga.edu

Graduate inquiries: chemgrad@uga.edu

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Fax: 706-542-9454

Head of the Department: Prof. Gary Douberly