Tags: Organic Seminar

Diazo compounds were first discovered by Peter Griess in 1858.1 The diazo group has been widely used due to its diverse reactivity, including alkylation, carbene generation, nucleophilic addition, homologation, and ring expansion.  These compounds can react with a wide number of transition metal complexes capable of transferring carbenes, including carbene insertion reactions into C–H, Si–H, N–H, O–H, and S–H bonds, sulfur ylide mediated…

    The Gelsemium alkaloids were first isolated from Gelsemium elegans and sempervirens in the 1870s. Despite their acute toxicity, they were documented for their potent analgesic properties and were first used in traditional Asian medicine. Our group achieved the first total synthesis of gelsenicine in 2016 using an Au(I)-catalyzed cycloisomerization/Cope rearrangement to forge the oxabicyclo[3.2.2]nonane skeletal…

Since approval by the FDA in 1989, erythropoietin (EPO) has been used extensively for the treatment of anemia – especially in those with chronic kidney disease, undergoing chemotherapy, or have acquired immune deficiency syndrome (AIDS).1 EPO is a highly glycosylated glycoprotein containing three N-linked and one O-linked glycosylation sites. These glycans constitute 40% of the weight of the glycoprotein and are important for activity.2 It has…

Nanoparticles (NPs) are particles of approximately 1-100 nm in size and have properties not found in bulk samples of the same material. Different materials, such as polymers, metal oxides, silica, noble metals, and carbon, can be used to create nanoparticles, which can then carry a variety of bioactive substances for use in biomedical applications, such as proteins, nucleic acids, small molecules for chemotherapy, and diagnostics. Owing to their…