Tags: Analytical Seminar


The Structural Role of N-Glycosylation in interactions between Antibodies and Receptors

Immunoglobulin G1 (IgG1) is the most abundant circulating human antibody and also the most common scaffold for therapeutic monoclonal antibodies (mAbs). The destruction of IgG-coated targets by cell-mediated pathways begins with an interaction between the IgG Fc region and multiple varieties of membrane-bound Fc g receptors (FcgRs) on the surface of leucocytes. This interaction requires the presence of an asparagine-linked (N-)glycan…


Leveraging structural biology to dissect calcium modification of ion channel function

In response to changes in calcium concentration, the intracellular calcium sensing protein calmodulin (CaM) alters the function of many proteins throughout the body. Many of these processes are important for normal physiology. Loss of function, miss-function, or untimely CaM function can cause or contribute to disease; some of which can be life threatening. There is a growing appreciation for the wide range of conformations and binding…


Exploration of the Bacterial Lipidome using Hydrophilic Interaction Chromatography and Ion Mobility-Mass Spectrometry

The bacterial lipidome has recently gained appreciation as an important factor in antibiotic resistance and host-pathogen interactions during infection. However, the study of bacterial lipids can be particularly challenging due to the presence of lipid species that are unique to bacteria in general, as well as several lipid classes that are unique to individual species of bacteria. Ion mobility-mass spectrometry (IM-MS) is a rapid gas-phase…


Multi electrode harmonized Kingdon traps as mass analyzers for FT based mass spectrometers

Kingdon trap [1] is the simplest ion trap consisting of wire and cylindrical electrode surrounding with different potential.  Well-known Orbitrap [2], has emerged as development of R. D. Knight’s idea [3], who modified the cylinder electrodes geometry to make the field inside Kingdon trap quadratic (harmonic) and proposed measuring the frequencies of ions oscillating in such field by resonant excitation of their motion along trap axis, to…


Giant Magnetoresistance Based Spin Valve Sensor for Biomolecule Detection

Ever since its discovery in 1988 by two research groups in France and Germany, Giant Magnetoresistance (GMR) has revolutionized the application of magnetic sensors in hard disk drives and magnetic memories.1,2 It also offers an inspiration for their use in magnetic biodetections, a growing field with great promises. One of them is the spin valve (SV) sensor, a magnetic field sensor sensing the magnetic fringing field of captured magnetic…


TBA


TBA


Characterization of Hydrophilic Post Translational Modifications by LC-MS

Post Translational Modifications (PTM) are modifications which take place following protein biosynthesis. There are hundreds of PTMs which have been discovered and possibly many more which have yet to be discovered. The analysis of the 20 amino acids to study has exponentially increased to seemingly limitless combinations of proteins and PTMs, and this number of possible PTM combinations add daunting challenges for proteomic analysis. The most…


Interaction between heparan sulfate and the Roundabout receptor at the single-molecule level

Scanning probe microscopy methodologies have advanced to the point that in situ measurements of complex biological systems can be routinely measured at the single-molecule level1, providing information on rare states that can be lost in standard ensemble measurements2and allowing highly specific detection of various proteins and polysaccharides3,4. One such system that has attracted considerable attention is that of the cell signaling pathway…


Chemical exchange and saturation transfer (CEST) based magnetic resonance imaging (MRI)

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