Skip to main content
Skip to main menu

Slideshow

Building Superior Biomolecules: Enhancing ADCs, Replacing ELISA, and Resurrecting ADEPT

Shawn Owen
Shawn Owen
Department of Pharmaceutics & Pharmaceutical Chemistry
University of Utah
Chemistry Building, Room 400
Analytical Seminar

Antibodies are important biological scaffolds used in biotherapeutics and diagnostics. The utility of antibodies can be expanded by coupling them with small-molecule drugs or proteins. Using both protein engineering and bioconjugation chemistry, we have created a series of highly-characterized antibody-conjugates that simultaneously deliver multiple drugs to induce new forms of synthetic lethality. Using these platforms, we are able to significantly increase the amount of drug that reaches a therapeutic target and demonstrate the applicability against HER2 positive cancers, as well as, drug-resistant bacteria. In separate approaches, we are utilizing split-enzyme technology to construct a new class of antibody-mediated diagnostics. These ‘wash-free’ homogenous immunoassays are as sensitive and more rapid than current technologies, without cumbersome processing steps. We have successfully constructed assays to measure protein biomarkers to follow cancer treatment and assays to monitor therapeutic drug levels. We are currently applying our platform to investigate important protein-protein interactions.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: chemreg@uga.edu 

Registration and credit transferschemreg@uga.edu

AP Credit, Section Changes, Overrides, Prerequisiteschemreg@uga.edu

Graduate inquiries: chemgrad@uga.edu

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Fax: 706-542-9454

Head of the Department: Prof. Gary Douberly