Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer

Slideshow

Protein Engineering to Modulate Autoimmunity

Mingnan Chen
Pharmacy School
University of Utah
Chemistry Building, Room 400
Analytical Seminar

Immunostasis is maintained by tolerance mechanisms like the programmed death-1 (PD-1) immune checkpoint.  With the immunostasis, the immune system is able to defend against infections and cancer without causing autoimmune disorders. However, immune stimulation signals override the PD-1 immune checkpoint in autoimmune diseases, and the checkpoint is no longer able to sustain immunostasis.  What drives Dr. Chen’s research is to improve therapies for autoimmune diseases by restoring immunostasis. Taking back control of the PD-1 immune checkpoint is one strategy to regain immunostastasis. To this end, multiple families of protein tools were engineered by leveraging the principles of immunology and protein engineering. In this seminar, discoveries and lessons that were learned from using these tools to modulate the PD-1 immune checkpoint will be presented and discussed.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: chemreg@uga.edu 

Registration and credit transferschemreg@uga.edu

AP Credit, Section Changes, Overrides, Prerequisiteschemreg@uga.edu

Graduate inquiries: chemgrad@uga.edu

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email: chem-web@franklin.uga.edu

Head of Chemistry: Prof. Jason Locklin