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Slideshow

Tags: Special Seminar

The conformation and post-translational modification (PTM) of a protein is critically important to its function. Mass spectrometry has been increasingly utilized to analyze both of these attributes. Acidic PTMs, like phosphorylation and sulfation however, present significant obstacles to analysis. Here, I present a series of techniques to overcome these issues and improve the annotation of these vital modifications. Lastly, I discuss the use of…
Sensing of ions is an integral part in bioanalysis and in the management of healthcare, water, the environment, and a range of industrial activities (e.g., agriculture and food processing). Traditionally, ion sensing was performed by sending samples to central test laboratories. Once the analysis is performed by the technician, the results are reported back to the customer or the healthcare provider. This process is time consuming and impedes…
An emerging strategy for discovering the next generation of catalysts involves utilizing high-level computational methods to predict and screen structure/function relationships. Effective comparison of theory and experiment requires that the theoretical and experimental models map onto one another perfectly. We use novel synthetic methods, advanced characterization techniques, and density functional theory calculations to approach this ideal. In…
It will be shown that the peculiar electronic and steric properties of cyclic (alkyl)(amino)carbenes (CAACs) (1,2) and other stable singlet carbenes allow for the stabilization of unusual diamagnetic and paramagnetic main group element species. As examples, we will describe the preparation of room temperature stable boron, antimony-, and even carbon-centered neutral and cationic radicals. We will also show that CAACs allow for the isolation of…

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