Tags: Materials Chemistry and Nanoscience Seminar


7-Dehydrocholesterol Encapsulated Lipid Nanoparticles as a Radiation-activated Radiosensitizer

The pursuit of therapeutics that can be selectively activated by radiation to enhance radiotherapy's efficacy is a pressing need. In this study, we utilized 7-Dehydrocholesterol (7DHC), a biosynthetic precursor of cholesterol, as a lipid targeted radiation-induced radiosensitizer (RIRS) for non-small cell lung cancer (NSCLC). 7DHC, reacting with radiation-induced reactive oxygen species (ROS), initiates a radical chain reaction with…


A Century of Teaching Inorganic Chemistry

Over the past century, the teaching of undergraduate inorganic chemistry has experienced a roller coaster of implementation. Starting with a separation from general chemistry, to recombination, then overall neglect, inorganic chemistry content and instruction have had a dynamic influence in the world of chemical education. With curriculum changes beginning in the late 1920s, American Chemical Society (ACS) guidelines have been continually…


Guest Speaker: Dr. Andrey Zakharchenko

Heart disease remains the leading cause of death worldwide. Heart valve disease is life-threatening in which heart valves do not function properly. Surgery is required to repair or replace the damaged valve for severe valve disease. Bioprosthetic heart valves are made from animal-derived materials, such as bovine pericardium (BP) or porcine heart valves, often work for many years in adults. However, when used in children, they tend to fail as…


Advances in Red Blood Cell-based Biomimetic Carriers for Drug Delivery

The evolution of drug delivery systems in the past decades has held great promise for enhancing efficacy of pharmacological agents, however, premature clearance from the circulation, toxic bioaccumulation, and inefficient site-specific delivery are still the major barriers to successful clinical translations. Bioinspired carriers possess natural components similar to the host, and hence are more biocompatible, less toxic, and less immunogenic.…


Self-healing Polymers: Characteristics and Applications

The replacement of construction materials such as pipelines, coatings, and seals and biomedical materials such as wound dressings and dental fillings is costly and time consuming. Oftentimes, such inconvenience could be avoided if the lifespan of the materials can be prolonged. Self-healing polymers are promising alternatives and solutions to these materials in some of the important fields including construction, commercial product, biomedical…


Suture Materials: Current and Emerging Trends

Sutures are special threads used in surgical procedures to enable closing and healing of surgical or trauma-induced wounds by upholding tissues together to facilitate healing process. Versatile suture materials are available for medical purpose. However, no single suture material is considered ideal for all situations, requiring clinicians to balance various properties when choosing a material for a particular application. Recent advancements…


Ultra-Low Fouling Coatings for Antimicrobial Biomaterials

Antimicrobial coatings are a promising route to prevent healthcare-acquired microbial infections caused by bacterial pathogens in medical contexts.1 To solve the problem of microbial biofouling, surfaces that can passively resist bacterial adhesion have been investigated. Surfaces with unique wetting phenomena have been proposed to reduce general biofouling, but to date, mainly superhydrophobic surfaces, surfaces that prevent water adhesion…


Heterogeneous Nucleation of Poly(hydroxybutyrate-co-hydroxyhexanoate)

Nucleation comprises the initial step of polymer crystallization, wherein the polymer melt stabilizes into ordered local structures, allowing for points from which polymer crystals can begin to grow. Nucleation quality can significantly impact the materials properties and processability of a polymer and is therefore of high importance to the materials science community. However, the collective understanding of polymer nucleation remains largely…


Design of Low-Dimensional Optical and Magnetic Chalcogenide Materials

Chalcogenides are compounds of the group-16 elements or chalcogens (Q), consisting of O, S, Se, and Te. Because O differs significantly in electronegativity (3.5 for O compared to 2.5 for S, 2.4 for Se, and 2.1 for Te), oxides are typically distinguished from the rest of the chalcogenides, which exhibit strongly covalent character. Metal chalcogenides have found applications in wide ranging areas as optical materials, magnetic materials,…


Adaptations of Cells and Tissues to Spatiotemporally Dynamic Mechanical Environments

In recent years significant progress has been made towards understanding the molecular and cellular mechanism by which cells “feel” their environment. There exists a complex relationship between the behavior of a cell, its physical properties, and its surrounding environment. Materials and devices with the ability to characterize cells and tissues in time and in response to changing stimuli have the potential to reshape our understanding of how…
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