Tags: Analytical Seminar


The Great ESKAPEE: Multi-Omic Methods for Bacterial Profiling Using HILIC-IM-MS

The prominence of antibiotic resistant bacterial strains has raised concern for the efficacy of currently available antibiotics. Point-of-care utilization of existing drug therapies require strain specific identification of pathogens, which often demands tedious sample preparation strategies and tailored analytical methods. The emergence of multi-omics approaches has empowered scientists to answer complex systems biology questions regarding…


Approaches for Quantifying Aerosol Mixing State Using Single-Particle Mass Spectrometry

While it is well established that atmospheric aerosols directly interact with solar radiation and indirectly alter cloud physical properties, there remains a sizeable uncertainty in aerosol influence on climate.1 Challenges in constraining aerosol influence arise from their complexity at the individual particle-scale as well as the global-scale. At the particle-scale, aerosols may be internally mixed, being comprised of many different molecular…


Traveling Wave-Ion Mobility-Mass Spectrometry for Multi-Omics Studies

In the field of omics, while single omics techniques have proven adequate, it has been observed that using multiple omics techniques in conjunction yields more thorough and informative sample profiles. The rapid gas-phase structural separation of ion mobility-mass spectrometry is beneficial for high-throughput multi-omics. However, implementing multi-omic methodologies with ion mobility separation presents several challenges, including the…


Quantification of Per- and Polyfluoroalkyl Substances from PM2.5 using LC-MS

Particulate matter (PM) is a mixture of solid or liquid particles suspended in a gas. Fine particles with diameters smaller than 2.5 mm (PM2.5) present a large human health concern because they can penetrate lower into the respiratory tract causing cardiovascular and respiratory diseases and lung cancer. A group of organic compounds previously observed in PM2.5, per- and polyfluoroalkyl substances (PFAS), are present in a variety of…


Measuring Isotope Incorporation in Proteins Produced Using Uniform or Sparse Labeling with 13C and 15N

Sparse labeling is a strategy for isotopic enrichment in proteins grown in mammalian systems, such as glycoproteins. We have developed a customized isotope simulator that can simulate enriched peptide and protein isotope patterns. Using this simulator, we have developed a software to experimentally determine the abundance of 13C and 15N in enriched peptides and proteins using isotope patterns and mass information from conventional mass…


Mass Spectrometry Application in Atherosclerosis (AS) Biomarkers Detection

Atherosclerosis (AS) is caused by fatty deposits, also called cholesterol accumulation in the arteries. The deposits mainly consist of cholesterol, fatty substances, calcium, and fibrin. Atherosclerosis is considered the major cause of cardiovascular diseases mainly involving the heart and brain: coronary arterial disease and ischemic stroke. It is the leading cause of death worldwide, inducing a severe financial burden in the world.…


Characterization of the Interaction of the Regulator of G-protein Signaling 10 (RGS10) and the Calcium Signaling Protein Calmodulin

Characterization of the interaction of the regulator of G-protein signaling 10 (RGS10) and the calcium signaling protein calmodulin G-Protein Coupled Receptors (GPCRs) are of high therapeutic importance, being the targets of approximately 35% of all drugs currently in clinical use. G-Protein activation upon agonist binding to a GPCR is mediated by the exchange of GDP to GTP in the G𝛼 subunit of the heterotrimeric G-Protein, which causes the…


Diagnosis of Infectious Diseases by Ion Mobility Mass Spectrometry

There is a projection of 10 million deaths per year by 2050 due to antimicrobial resistance, highlighting the need for rapid detection and accurate identification of microorganisms. Therefore, developing fast robust diagnosis techniques will increase the recovery rates of patients suffering from various infections and will lead to significantly reduced antibiotic resistance. The membrane of bacteria contains varying lipid compositions that can…


Multi-Dimensional Separations for Bacteria Identifications and Investigations of Antimicrobial Resistance

Bacterial infections are a major global health concern, with an estimated 1 in 8 deaths attributed to bacterial infections in 2019 alone. When a patient with a suspected infection arrives in a clinical setting, the first step to developing a treatment strategy is to identify the causative pathogen, followed by determination of antimicrobial therapeutics that are appropriate and effective. The challenge for both these essential steps is the…


Imaging Biological Tissues at High Chemical and Spatial Resolutions Using Mass Spectrometry

Imaging mass spectrometry is a powerful analytical technique for analyzing the spatial lipidome. This technology enables the visualization of molecular pathology directly in tissues by combining the specificity of mass spectrometry with the spatial fidelity of microscopic imaging. This label-free methodology has proven exceptionally useful in research areas such as cancer diagnosis, diabetes, and infectious disease. However, state-of-the-art…
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